![]() AEs are dose dependent, and risk is amplified by drug interactions that functionally increase statin potency, often through inhibition of the cytochrome P450 (CYP)3A4 system. A number of manifestations of muscle AEs have been reported, with rhabdomyolysis the most feared. In meta-analyses of randomized controlled trials (RCTs), muscle AEs are more frequent with statins than with placebo. We hypothesize, and provide evidence, that the demonstrated mitochondrial mechanisms for muscle AEs have implications to other nonmuscle AEs in patients treated with statins. Evidence regarding the statin muscle AE mechanism, dose effect, drug interactions, and genetic predisposition is examined. Here we review the statin AE literature, first focusing on muscle AEs as the most reported problem both in the literature and by patients. Statin use and the risk of cataracts: A systematic review and meta-analysis.HMG-CoA reductase inhibitors (statins) are a widely used class of drug, and like all medications have potential for adverse effects (AEs). The role of statins in both cognitive impairment and protection against dementia: A tale of two mechanisms. Summarizing the current state of evidence on efficacy and safety of statin therapy. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. We link primary sources - including studies, scientific references, and statistics - within each article and also list them in the resources section at the bottom of our articles. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations.
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